[28] Moreover, C/EBPβ and –δ have been implicated in the regulation of pre-pro-ET-1 in response to mechanical forces, suggesting that these transcription factors might have a role in modulating vascular tonus by regulating ET-1 synthesis in hypertension. [29] However, there are no data regarding the role of C/EBP family in diabetes and their possible impact on ET-1 expression in EC. The gene discussed is EDN1; the disease is diabetes mellitus.