To investigate the effects of Ad-NDRG2 on tumor growth in vivo, we injected adenovirus (1 x 109 pfu in 100 ul PBS) Ad-NDRG2, Ad-LacZ or PBS every 3 days into pre-established human 786-O renal cancer tumors (approximately 200 mm3) grown in nude mice. Here, NDRG2 is linked to renal carcinoma.