Furthermore, idelalisib affects CLL cells migration beneath BMSC, chemotaxis towards the chemokines CXCL12 and CXCL13, and disrupts BCR signaling and BCR-induced secretion of the CLL cell-derived chemokines CCL3 and CCL4 [16]. This evidence concerns the gene CXCL13 and B-cell chronic lymphocytic leukemia.