Over-expression of the lipogenic genes such as SREBP-1c, FAS, and ACC1 in obese individuals have been shown to be strongly associated in the development of chronic NAFLD, a broad spectrum of liver abnormalities ranging from simple hepatic steatosis to a more severe form, non-alcoholic steatohepatitis (NASH), which is associated with hepatocyte damage, chronic inflammation, and fibrosis, and may progress to cirrhosis and liver failure [36]. Here, SREBF1 is linked to metabolic dysfunction-associated steatohepatitis.