It has been suggested that in DM1 CUGBP1 may be responsible for muscle wasting since the transgenic mice with skeletal muscle-specific expression of CUGBP1 reproduces the dystrophic muscle histology characteristic of DM1 [67] while MBNL1 knockout mice do not exhibit severe muscle wasting suggesting that MBNL1 depletion alone is not able to reproduce this disease feature [68]. This evidence concerns the gene CELF1 and myotonic dystrophy type 1.