Since it has been reported that activation of Akt pathway increases CUGBP1 phosphorylation at S-28 in DM1 myoblasts and skeletal muscle, we tested if the increase of CUGBP1 expression observed in our DM cohort is related to an increase of CUGBP1 phosphorylation at S-28. This evidence concerns the gene AKT1 and myotonic dystrophy type 1.