CTLA4 and autoimmune disease: Among the CTLA-4 gene polymorphisms, two polymorphisms including CTLA4 60G/A (rs3087243) in the 3’-UTR, and CTLA4 -1661A/G (rs4553808) in promoter region were widely studied and have been reported to be associated with susceptibility to inflammatory diseases, autoimmune diseases and cancers [9], [10].