The positive correlation of PGK1 and CXCR4 expression in neuroblastoma patients as well as the downregulation of PGK1 through inhibition of the CXCR4 receptor, which we found in our in vitro studies, are indicators for a causal interaction between the PGK1 pathway and the CXCR4/SDF1 axis. Here, CXCL12 is linked to neuroblastoma.