CXCL12 and neoplasm: PGK1 also appears to be a crucial enzyme for peritoneal dissemination of gastric cancer in both CXCR4/SDF1-dependent and by CXCR4/SDF1-independent mechanisms, making high levels of PGK1 essential for tumor growth and metastasis and showing a direct relationship between PGK1 signalling and CXCR4 [31], [32].