FOXO3 and infection: Fig. S2E indicated that lentiviral overexpression of FOXO3A protein significantly induced protein expression at multiplicity of infection 20. Our experimental data demonstrated that overexpression of FOXO3A significantly impaired proliferation, migration and tube formation of either HCMV or mock-infected ECs whereas transfection of FOXO3A siRNA enhanced these angiogenic responses(Fig. 2D, 2E, 2F and Fig. S2F and S2G).