CD204(+) macrophages reportedly exhibit a tumor-promoting function in several tumors by secreting matrix metalloproteinase (MMP)-1, MMP-3, MMP-7, MMP-9, MMP-12, vascular endothelial growth factor (VEGF), and transforming growth factor (TGF)-β [26], [27]. This evidence concerns the gene TGFB1 and neoplasm.