In non-small cell lung cancer (NSCLC), the expression of CIC/CSCs-related markers, for example aldehyde dehydrogenase1 (ALDH1), octamer-binding transcription factor 4 (OCT4), NANOG, SRY-box 2 (SOX2), and Caveolin-1, were reportedly correlated with treatment resistance, and disease recurrence, and survival [8]–[11]. This evidence concerns the gene POU5F1 and non-small cell lung carcinoma.