The excessively high expression of Id2 in anchorage dependent cells, its function as an effector of n-myc and an oncogenic factor in neuroblastoma [27] as well as its contribution towards negative regulation of cell differentiation and positive regulation of cell cycle control [27], [32], [46] led us to investigate its role as a mediator of adaptive plasticity in neuroblastoma. Here, ID2 is linked to neuroblastoma.