We further report that APRIL was co-expressed with CXCL12, CCL11 and IL16 [61], IL2Rγ, CD4 and CD52 [62] and IL10R, TBXAS1 and CD86 [63], while BAFF was co-expressed with β-microglobulin and CX3CR1 [64], IgSF21 [65], CX3CR1 [62] or TNFSF10 (TRAIL) and the chemokines CXCL9, 10 and 11 [63], suggesting that these ligands are part of the immune response of glioma tumors. The gene discussed is IGSF21; the disease is central nervous system cancer.