Consistent with a conserved role of MCH in colitis, we found that intestinal MCH2 mRNA was significantly upregulated in zebrafish treated intrarectally with TNBS: 100 ± 41 vs. 353 ± 49 AU; vehicle vs. TNBS; n=9-10 fish per group; p=0.0065 (Figure 7A). This evidence concerns the gene MCHR2 and colitis.