We used COMP ELISA Assay and determined that COMP concentrations were significantly increased in the serum of IPF patients when compared with controls (P-value = 0.004, mean = 9.977 and SD = 4.422 for IPF and mean = 6.475 and SD = 2.473 for controls (Figure 6A). This evidence concerns the gene COMP and idiopathic pulmonary fibrosis.