Of these, 8 SNPs including IGF2BP2 rs4402960, WFS1 rs734312, CDKAL1 rs7756992, SLC30A8 rs13266634, CDKN2A/B rs10811661, HHEX rs7923837, TCF7L2 rs7903146 and KCNQ1 rs2237892 were consistently and significantly associated with T2D after adjusting for sex, age and BMI (OR = 1.14–2.09, 8.5×10−18<P<8.5×10−3) (Table 2). The gene discussed is KCNQ1; the disease is type 2 diabetes mellitus.