NPC1 and Niemann-Pick disease type C: Chen et al. (2010), using wild type BALB/c and NPC1 mice (a experimental model for Niemann Pick Type C disease which is characterized by cholesterol accumulation in the endosomal/lysosomal system), reported that 2-hydroxypropyl-beta-cyclodextrin (HPβC) alone was also able to induce lysosomal exocytosis without the concomitant use of calcium ionophores.