Expression and/or activation of the mitogen-activated protein kinase MAPK (RAS/RAF/ERKs) and phosphatidylinositol 3-kinases (PI3Ks)/protein kinase B (PKB-AKT)/mammalian target of rapamycin kinase (mTOR) pathways are abnormally high in many HCC cells, which render the latter resistant to apoptotic stimuli [18]–[22]. The gene discussed is MTOR; the disease is hepatocellular carcinoma.