A typical example is the prevention by ACR of the aberrant hyper-phosphorylation and inactivation of retinoid X receptor (RXR) α that occurs during carcinogenesis in HCC [12] and the subsequent induction of apoptosis in HCC cells by the restoration of the expression of RXRα downstream genes such as p21 [11], transglutaminase 2 (TG2) [5] and more. This evidence concerns the gene TGM2 and hepatocellular carcinoma.