Similarly, both of TLR4 rs4986790 (allele comparison: OR = 1.17, 95% CI: 1.00–1.37, P<0.001 for heterogeneity test; dominant model: OR = 1.19, 95% CI: 1.01–1.41, P<0.001 for heterogeneity test) and rs4986791 (allele comparison: OR = 1.47, 95% CI: 1.21–1.78, P = 0.070 for heterogeneity test; dominant model: OR = 1.47, 95% CI: 1.20–1.80, P = 0.078 for heterogeneity test) also significantly increased the overall cancer risk. Here, TLR4 is linked to cancer.