Considering the relatively small sample size in each single study might have low power to detect the effect of the polymorphisms on cancer risk and the underlying heterogeneity among different studies need be explored, we conducted a meta-analysis on all eligible published case-control studies to establish a relatively comprehensive picture of the relationship between these genetic variants (−196 to −174 del in TLR2, rs4986790 and rs4986791 in TLR4) and cancer risk. Here, TLR4 is linked to cancer.