The results indicated that variant genotypes of TLR2 −196 to −174 del tended to be associated with overall cancer risk in Caucasians (allele comparison: OR = 3.29, 95% CI: 1.14–9.51, P<0.001 for heterogeneity test; dominant model: OR = 3.56, 95% CI: 1.10–11.51, P<0.001 for heterogeneity test) and South Asians (allele comparison: OR = 1.32, 95% CI: 1.11–1.58, P = 0.785 for heterogeneity test; dominant model: OR = 1.37, 95% CI: 1.11–1.68, P = 0.870 for heterogeneity test), but not in East Asians (Table 2). This evidence concerns the gene TLR2 and cancer.