TLR4 and cancer: However, a recent meta-analysis of 22 publications on six selected SNPs (rs1927914, rs4986790, rs4986791, rs11536889, rs1927911 and rs2149356) in TLR4 and cancer risk reported that TLR4 rs4986790 and rs4986791 were significantly associated with increased risk of overall cancer and significantly elevated risk of gastric cancer was observed for rs4986790 in a stratification study [60].