ATM and obesity due to melanocortin 4 receptor deficiency: Figure 4D showed clearly that most of the genes aligned well along the diagonal line. Only 53 genes were differentially regulated (fold differences >2.0 and p<0.05) and these are listed in Table 2. Again, they included very few inflammatory mediator genes. These data together (Figs. 2–>4) showed strongly that salicylates do not improve obesity-induced insulin resistance by modulating ATM recruitment or activation.