The inhibition of STAT3 by LLL12 also down-regulated the expression of known STAT3 target genes in ALDH+ breast cancer cells related to cancer cell proliferation, survival, and angiogenesis, including Cyclin D1, survivin [19], Bcl-2, Bcl-XL [9], MMP-2, and MMP-9 [21], [22] (Figure 2C). Here, MMP2 is linked to breast cancer.