The inhibition of STAT3 by LLL12 also down-regulated the expression of several known STAT3-regulated genes in breast cancer stem-like cells such as Cyclin D1, survivin [19], Bcl-2, Bcl-XL [9] and an IL-6 regulated gene, Notch1 [23] (Figure 5C). This evidence concerns the gene BIRC5 and breast cancer.