Although interferon (IFN)-γ production by lymphocytes was detected in the supernatant cultured with B cell lines without virus infection (Figure 4A), IFN-γ production by lymphocytes obtained from the vaccinated macaques except Ho4 and Ho5 was significantly up-regulated in the presence of APC infected with challenge virus (P<0.05). The gene discussed is IFNG; the disease is viral infectious disease.