While our in vivo studies showed that patients with ovarian tumors positive for the cytotoxic molecules TIA-1 and granzyme B in CD31 and VEGF-low tumors had decreased survival compared to those with cytotoxic molecules expressed in CD31 and VEGF-high tumors, these observations were not as drastic as those observed in vitro. This evidence concerns the gene TIA1 and ovarian neoplasm.