Guanine nucleotide binding protein beta-3 (GNB3) variants C825T and Ser275Ser(M/N) [rs5443] may be associated with hypertension elevation responsible for decreased longevity, and GNB3 may be implicated in obesity, coronary artery disease, left ventricular hypertrophy, and diabetes mellitus [17]. Here, GNB3 is linked to obesity due to melanocortin 4 receptor deficiency.