Furthermore, eNOS 298 without TT may be correlated to longer life without dementia, and variations in the frequencies of genotypes and alleles of GNB3 825C/T between the centenarian group and the control group suggest a strong association between the genotype CC of the polymorphic locus 825CC in the GNB3 gene and the longevity of Uygur persons. This evidence concerns the gene NOS3 and dementia.