Aging patients may be potentially susceptible to eNOS-induced abnormal NO signaling in the brain, which has been linked a variety of neurodegenerative pathologies such as stroke and excitotoxicity, Alzheimer's disease, multiple sclerosis, and Parkinson's disease, conditions responsible for dementia in a large portion of the geriatric population [35]. The gene discussed is NOS3; the disease is early-onset autosomal dominant Alzheimer disease.