IFNG and disease arising from reactivation of latent virus: Evidence suggests that states of persistent low antigen load and long-term immune control such as treated TB, latent infection, and BCG vaccination are associated with an immunological profile dominated by dual IFN-γ/IL-2-secreting TEM cells and IL-2-secreting TCM cells; on the contrary, active TB is predominated by IFN-γ-only-secreting TEMRA cells [12, 20, 26, 27].