A relatively early study assessed the presence of a particular chemokine (CXCL12) and its specific receptor (CXCR4), revealing that the receptor was more prevalent in oral cancers that metastasized, suggesting that this chemokine/receptor may be important in the regulation of tumour growth and organ-specific lymphatic spread [61]. The gene discussed is CXCL12; the disease is lip and oral cavity carcinoma.