Previously, investigations based on the known association between the chemokine ligand CXCL13 and prognosis of oral cancer found that the chemokine ligand/receptor axis of CXCL13/CXCR5 is not only important for cancer bone invasion and metastasis but may also be a potential therapeutic target to prevent OSCC bone invasion/osteolysis [72]. This evidence concerns the gene CXCL13 and lip and oral cavity carcinoma.