Together iDCs and semi-mature DCs tend to encourage T cell anergy or T cell exhaustion (9, 10), tolerogenicity toward the cancer cell (9, 31), and even active pro-tumorigenic activity (e.g., semi-mature DC-derived IL-6 may act as a growth factor for tumors expressing IL-6R-gp130 cognate receptors and/or IL-10 can act as a general immunosuppressor) (17, 40, 41). This evidence concerns the gene IL10 and cancer.