LMNA and Emery-Dreifuss muscular dystrophy: There are two B-type lamins that originate from two genes, LMNB1 and LMNB2. The A-type lamins, Lamin A and Lamin C, are, respectively, the immature and fully processed gene products of the LMNA gene and will be the forms discussed here; it is these proteins that directly contribute to nuclear positioning in muscles, and mutations in the LMNA gene result in the autosomal dominant form of EDMD (Stewart et al., 2007).