Our results raise the possibility that the TPJ may represent a novel treatment target in stress related disorders, although an important question in this context is whether the effects of SRX246 are mediated directly by AVPR1a in the region itself or indirectly via connected substructures such as the amygdala, lateral septum, posterior cingulate, or thalamus that, based on studies in rodents and non-human primates, are known to express vasopressin receptors (Young et al., 1999; Phelps and Young, 2003). This evidence concerns the gene AVPR1A and stress-related disorder.