Furthermore, several findings in vitro suggest that adiponectin may actively promote RA progression as it induces the secretion of proinflammatory molecules (e.g., IL-6, COX-2), chemokines (e.g., IL-8, MCP-1), and matrix-degrading enzymes (e.g., MMP-3) in vitro [64, 65]. This evidence concerns the gene ADIPOQ and rheumatoid arthritis.