ADIPOQ and rheumatoid arthritis: Indeed, adiponectin stimulation increased protein secretion in OA fibroblasts to a much lesser extent than in RA [32, 64] suggesting that, as observed in RA, some adiponectin isoforms may be more detrimental than others, but also that OA fibroblasts show in general a weaker response to adiponectin stimuli than RASF.