LEP and Insulin resistance: Focusing on the context of this review, related to the implication of adipocytokines for the cardiovascular risk, the only speculations may be done on adiponectin and leptin (see Figure 1): in RA, the first was shown to be reduced in obese patients or in those with rheumatoid cachexia and inversely correlated with radiographic damage [78, 84]; the latter was associated with insulin resistance [99], but the consequences of these association have not been further studied.