In contrast to findings in other inflammatory diseases [18, 63], both RA synovial tissue and articular adipose tissue were a significant source of adiponectin, capable of stimulating RASF to produce IL-6 and prometalloproteinase-1, a finding that supports an active role of this adipocytokine in the pathogenesis of RA [62]. Here, IL6 is linked to rheumatoid arthritis.