TNF and Crohn disease: At first glance, the fact that TNF ablation corrected the inflammatory phenotype that characterises cpdm mice may not seem overly surprising, given that inhibition of TNF has been proven to be a highly successful therapeutic approach for the treatment of several chronic inflammatory and autoimmune diseases, including psoriasis, psoriatic arthritis, rheumatoid arthritis and Crohn's disease 196, 197, 198.