ADAM8 and breast cancer: Immunohistochemical analysis of 56 human breast cancer-derived metastases revealed that 48.2% (27/56) were positive for ADAM8 expression (Fig 4I), including the majority of brain metastases (63%), and significant percentages of lymph nodes (44.5%), liver (29.4%) and other organ metastases (33.3%, 1/3).