DYRK1A and Dravet syndrome: Moreover, Dyrk1A transgenic mice carrying an extra copy of Dyrk1A, exhibit features similar to those observed in DS patients including hippocampal-dependent memory tasks, arrest of neurogenesis and altered synaptic plasticity (Smith et al, 1997; Altafaj et al, 2001; Ahn et al, 2006; Das & Reeves, 2011; Martinez de Lagran et al, 2012).