Furthermore, a Multivariate analysis indicated that lymph node metastasis (N P = 0.004), distant metastasis (M P = 0.002), TNM stage (P = 0.017), and LRPPRC expression (P = 0.004) were independent prognostic factors of overall survival for the patients with gastric cancer. The gene discussed is LRPPRC; the disease is metastatic malignant neoplasm in the lymph nodes.