Similar to what was observed across the treatment groups in the overall patient population in the SELECT study [12], infections, cutaneous events and elevations of liver enzymes, defined as elevations of alanine aminotransferase/aspartate aminotransferase greater than five times the upper limit of normal (5× ULN), occurred more frequently with pooled DAC HYP treatment than with placebo treatment in both the highly active RRMS and less active RRMS subgroups (Table 2). Here, GPT is linked to infection.