In particular, signaling pathways involved in the regulation of proliferation and differentiation have been found to be affected in laminopathies, including pRb, mitogen activated protein kinase (MAPK), Notch, transforming growth factor β (TGF-β), sterol response element binding protein-1 (SREBP-1), NF-κB and Wnt/β-catenin pathways [4,10]. Here, RB1 is linked to laminopathy.