These mutations cause a variety of diseases, collectively termed primary laminopathies for lamin A/C-linked diseases and nuclear envelopathies for diseases linked to nuclear envelope proteins They affect different tissues (striated muscle, heart, fat, bone, skin, or neuronal tissues) in isolation or in various combinations, or cause premature aging diseases, e.g., Hutchinson–Gilford Progeria Syndrome (HGPS) [43–47]. The gene discussed is LMNA; the disease is Hutchinson-Gilford progeria syndrome.