In the current meta-analysis, a significant relationship existed between KCNQ1 rs2237892 C→T gene polymorphism and T2DM under allelic (OR: 1.350), recessive (OR: 0.650), dominant (OR: 1.450) and additive genetic (OR: 1.346) models in the Asian population. This evidence concerns the gene KCNQ1 and type 2 diabetes mellitus.