A significant relationship between KCNQ1 rs2237892 C→T gene polymorphism and T2DM was observed in the Asian population under the allelic (OR: 1.350; 95% CI: 1.240–1.480; P < 0.00001), recessive (OR: 0.650; 95% CI: 0.570–0.730; P < 0.00001), dominant (OR: 1.450; 95% CI: 1.286–1.634; P < 0.00001), and additive genetic models (OR: 1.346; 95% CI: 1.275–1.422; P < 0.00001; Table 2, Figs 1 and 2). Here, KCNQ1 is linked to type 2 diabetes mellitus.