New born rash, seborrheic dermatitis from 3 months, recurrent lower respiratory infections (> 6), pneumonia (X3), pneumatoceles, oral thrush, recurrent skin abscesses, typical facies, nasal width, fractures (left and right radius and ulna), Eosinophilia (> 800 / μl), IgE > 2000 IUml NIH Score 63*. This evidence concerns the gene IGHE and seborrheic dermatitis.