IGFBP1 and coronary artery disorder: Interestingly, even though evidence for an association of baseline IGFBP1 with CHD risk was weak, there was a nearly significant association (P = 0.06) of risk with change from baseline to year 1 in IGFBP1 concentration, and the OR for treatment was null (OR = 0.96) after controlling for IGFBP1 change.