B2M is an amyloidogenic protein that is elevated in hemodialysis patients [26,27], and has been reported to be positively associated with CVD risk factors [28] and with CVD events among patients having chronic kidney disease [29], asymptomatic carotid atherosclerosis [30], or peripheral arterial disease in a healthy elderly population [31]. This evidence concerns the gene B2M and carotid atherosclerosis.