For stroke there was some modest AUC increase from 0.645 (0.590, 0.700) without any such proteins added, to 0.663 (0.604, 0.718) when B2M was added, and to 0.665 (0.605, 0.722) when IGFBP4 was added, based on analyses that randomly divided the data into training and validation subsets with the model fitted in the training set used to estimate AUC in the validation set. The gene discussed is IGFBP4; the disease is stroke disorder.