With the longer-term data analyzed here the estimated CHD OR (95% CI) for a 30% increment in baseline B2M is 1.28 (1.08, 2.54) following year 1, and the stroke OR (95% CI) for a 30% increment in baseline IGFBP4 is 1.16 (1.03, 1.30) following year 1. Here, IGFBP4 is linked to stroke disorder.