Epigenetic silencing by promoter hypermethylation occurs at several tumor suppressor genes, such as SFRP1, APC, HHIP, SOCS1, CASP8, and RASSF1A. In addition, several imprinted genes, including IGF2, DLK1, PEG3, PEG10, MEG3, and NDN, have been reported to be overexpressed in hepatoblastoma [2]. This evidence concerns the gene IGF2 and hepatoblastoma.