IGF2 and Beckwith-Wiedemann syndrome: For example, hypermethylation of H19-DMR, which is the ICR of the IGF2/H19 imprinting domain at the 11p15.5 locus, is a cause of Beckwith-Wiedemann syndrome (BWS), the most common overgrowth syndrome characterized by occasional development of embryonal tumors, including hepatoblastoma [5].