HCN2 and Stroke: The findings of the presented study show: (1) during the course of stroke development hcn2 gene expression remains stable in infarcted cortical areas and reveals a significant decrease in affected basal ganglia 24 h after reperfusion compared to sham-treated animals; (2) the presence of HCN2 channels does not affect stroke development regarding infarct sizes and neurological as well as motor functions assessed from tMCAO-treated mice.