Mutations in the KRT5 gene have been reported since the early 1990s as the cause of epidermolysis bullosa simplex (EBS).9 Keratin 5, a type II keratin protein, partners with the type I keratin 14 and this keratin pair is predominantly expressed within the basal cells of the epidermis where blistering in EBS occurs. Here, KRT14 is linked to epidermolysis bullosa simplex.