NFKB1 and cancer: Furthermore, these CLA isomers may compete as ligands for the NF-κB transcription factor in cancer cells [34], and hence, the similar effects of c9,t11-CLA and t10,c12-CLA isomers on inhibiting MCF-7 cell proliferation might be due to similar binding affinities of the CLA isomers to NF-κB expressed in the cells.