The generation of high concentrations of NO through the activation of iNOS by immunostimulating cytokines or bacterial pathogens and the activation of inducible nuclear factors such as NF-κB may predispose an individual to inflammatory diseases, such as atherosclerosis, rheumatoid arthritis, diabetes, septic shock, and multiple sclerosis [41]. The gene discussed is NFKB1; the disease is rheumatoid arthritis.