Data from our present study suggests that an increased HMGB1 mRNA expression in the liver, kidneys, lungs, and ileum is associated with the damage of acute organ injury as shown by significantly elevated levels of plasma ALT, creatinine and activity of MPO in lungs, decreased activity of DAO in the ileum mucous membrane, and inflammatory histological alteration secondary to sepsis induced by CLP. This evidence concerns the gene GPT and Sepsis.