This is even more intriguing since elevated HMGB1 plasma levels have been identified to be independently associated with mortality and residual ventricular function in ST-segment elevation myocardial infarction treated by percutaneous coronary intervention (PCI) [35, 36], and carriers of the Arg753Gln polymorphism are at higher risk for coronary restenosis after MI and PCI [24]. The gene discussed is HMGB1; the disease is myocardial infarction.