HDAC4 and amyotrophic lateral sclerosis: In amyotrophic lateral sclerosis, a neurodegenerative disease characterized by loss of motor neurons and degeneration of target muscle fibers, miR-206 can delay progression of the phenotype by stimulating compensatory regeneration of neuromuscular synapses through targeting of histone deacetylases (HDAC4) and fibroblast growth factors (48).