CD4 and syphilis: This multivariate logistic regression modeling demonstrated that the predictive factors associated with serological failure after early syphilis treatment were a CD4 T-cell count below 350 cells/ml (OR 2.41; 95% [95% CI, 1.27-4.56]), syphilis history (OR 3.12 [95% CI, 1.55-6.26]), and baseline RPR titer ≤ 1:16 (OR 3.91 [95% CI, 2.04-7.47]), independent of other characteristics.