Meanwhile, TARDBP, encoding TAR-DNA binding protein (also known as TDP-43 proteins), is one of the principal genes responsible for the adult onset form of amyotrophic lateral sclerosis (ALS), displaying a TDP-43 positive skein-like inclusions in the anterior horn of the spinal cord and inferior olive [25]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.