TNF and Sepsis: Proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), IL-6, and IL-8, are necessary to initiate an effective inflammatory process in patients with sepsis [11]; however, somewhat to the contrary, anti-inflammatory cytokines such as IL-10, IL-13, IL-4, and transforming growth factor-β (TGF-β), are also found to be in a relative high level in septic patients [12, 13].