Insulin resistance and hypertension are improved when KKAy mice (mouse models of obesity and diabetes) are administered physiological concentrations of adiponectin, and insulin resistance is observed in KO mice deficient in adiponectin, suggesting that obesity-induced decreases in adiponectin expression in WAT are closely associated with the development of insulin resistance and the onset of diabetes [72, 73]. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.